The research represents a major step forward in revealing how the three dimensional form of DNA shapes the way human biology functions. In a major step toward understanding how the physical form of ...

Research reveals that five DNA letters can switch chromatin between fluid and solid-like states, influencing gene ...

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators and the 4D Nucleome Project have unveiled the most detailed maps to date ...

The human genome is no longer just a sequence to be read. It’s a dynamic structure that twists, folds, and reshapes itself in ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

This important study provides a detailed analysis of the transcriptional landscape of the mouse hippocampus in the context of various physiological states. The main conclusions have solid support: ...

If stretched out, human DNA would be about 2 meters long. For this long strand to fit inside the cell nucleus, which is about ...

There is a huge amount of DNA in most human cells, and that DNA has to be carefully compacted and organized so that it will ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...